pentobarbital will minimize the extent or outcome of estradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (title Beforehand used: bishydroxycoumarin) and brings about a decrease in anticoagulant activity as measured via the prothrombin time. Barbi